To identify host modifiable factors associated with improved response to single-dose albendazole. The Hookworm Exposure and Treatment (HEAT) sub-study will measure albendazole absorption and monitor response to single-dose albendazole following treatment in the context of the longitudinal study.

To investigate the individual and community-level factors associated with hookworm reinfection. The project will conduct longitudinal community studies of hookworm and schistosomiasis transmission and reinfection. Within this context, conduct sub-studies to characterize the role of individual movement patterns, maternal infections and animal husbandry as pathways to reinfection.

To develop a comprehensive anthelminthic response map (AR-Map) of sentinel sites in Ghana to aid in monitoring and surveillance of the effectiveness of national deworming programs in

Develop sensitive diagnostic tools for rapid monitoring of MDA effectiveness and detect any potential emerging drug resistance.

Contribute towards achieving the critical mass of health scientists on the African continent for NTD control and elimination through training, supervision and mentorship.